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Lyophilization is a complex process that presents many manufacturing challenges, one of which is maintaining and monitoring container closure integrity of the finished package. To help ensure the seal integrity and to detect raised stoppers on vials containing lyophilized drug products, 100% laser-based headspace analysis is increasingly being implemented. Download this brochure to learn how rapid, nondestructive laser-based headspace inspection detects vials having raised stopper issues. Data from ‘raised stopper vials’ is presented showing that quantifying the physical headspace conditions also enables science-based process troubleshooting and optimization. |